Long String Genomics
Because SIZE MATTERS
Analyzing long stretches of genetic material means leaping forward into the last frontiers in genomics.
Using such approaches will close existing gaps and unveil blindspots.
With automation solutions from Hamilton for these workflows, we aim to enable the scientific community to work at scale and make new discoveries
Automated Isolation of High Molecular Weight (HMW) DNA from Human Blood Samples with PacBio® Nanobind® Technology on the Hamilton NIMBUS® Presto - Next Level Preparation of Extracts for Long-Read SequencingLong-read sequencing technology provides great potential in several clinically relevant areas of human genomics. Recent advancements allowing increased sequencing throughput and accuracy at a more affordable cost have already been made. However, the applied workflows still contain bottlenecks, especially in the extraction process steps that increase variability in HMW DNA (50 kbp -250 kbp) yield and quality, while hindering the processing of higher sample numbers. Overcoming these hurdles by robust high-throughput, automated solutions will support the growing number of large-scale population genomics studies and clinical research applications.
Automated extraction of High Molecular Weight (HMW) DNA with PacBio® Nanobind® technology on the Hamilton NIMBUS® Presto Assay Ready WorkstationRapidly emerging long-read sequencing technologies, including PacBio Single Molecule, Real-Time (SMRT®) sequencing, provide substantial advantages for (de novo) genome assembly, detecting structural variants, and higher accuracy in repetitive or high GC content regions. A key requirement for long-read, third-generation sequencing approaches is the extraction of HMW DNA (50 kb – 250 kb). As the field matures and sample numbers increase, robust, high-throughput sample preparation methods are needed to support large-scale studies in pan-genomics and clinical research applications.
Whole Genome and Transcriptome Analysis for Leukemia DiagnosticsThe rationale behind the automation of the assay is mainly in terms of a quality improvement and enhancement of productivity, provided by minimizing the bias that might be otherwise introduced by manual library preparation. Moreover, the automated system is sufficiently flexible to adapt and therefore easily meet evolving needs
Advantages of Long String Genomics
Stepping into the most advanced genomic application areas
Novel technologies in genomics have revolutionized many aspects within life science. But the journey is far from over.
The analysis of relatively short nucleic acid molecules has been of fundamental importance in research and clinical usage. However, there are limitations which leave some questions unanswered. Until now.
With the opportunity to look at larger molecules, many limitations of current standard methods can be overcome and can provide a more comprehensive picture of the genome.
Reveal the UNSEEN
High Molecular Weight (HMW) DNA Extraction for Long-Read Sequencing
Automated on NIMBUS Presto
Learn more about PacBio Long-Read Sequencing
Learn more about Hamilton NIMBUS Presto
Resolve the UNDETECTABLE
Ultra High Molecular Weight (UHMW) DNA Extraction for Optical Genome Mapping Automated on Long String STAR V
Learn more about Bionano Optical Genome Mapping
Learn more about Hamilton Long String STAR V
Towards a better VIEW
See what Hamilton can do if you demand the bigger picture
Learn more about Hamilton’s Long String Genomics Solutions
Additional Resources for Genomics
Check out our free Booklet about Long String GENOMICS
Explore the Hamilton Long String STAR V
Learn more about the Hamilton Microlab NIMBUS
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