Characterizing a potential protein lead is the key to develop it into a successful drug however understanding the binding structure of compounds toward the protein backbone is the key to lead optimization. The field of protein therapeutics offers huge potential for developing treatments that are well tolerated and do not require frequent administration.
However, selecting a large molecule and determining that it is effective, safe and stable enough for cost-effective production and storage requires a thorough understanding of the molecule's structure, as well as how it behaves in the body and in the formulation. Protein crystallography is a powerful tool for unrevealing this puzzle.
Hamilton has automated several common processes used to characterize proteins in early research through quality control of the final product.