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Lead Selection and Optimization

Drug Discovery

Lead Selection and Optimization

After finding hits during the screening phase, these hits are optimized using newly synthesized analogs based on the chemical backbone of the hit structure.

The analogs are then tested for improved potency, improved drug-likeness,
and physicochemical/metabolic properties suggestive of reasonable in vivo pharmacokinetics using both, in vitro as well in vivo test systems.

The increased throughput and improved data quality required have prompted
the industry to adapt more and more automated solutions.

At Hamilton, we know how to automate a wide variety of assays for the selection
and optimization of lead components to increase throughput and data quality.

Years of experience during years in the business enable us to address different levels of automation and integration of third party devices customized to your needs.