X-Type syringes have a near zero carryover and a long-lasting plunger tip to meet the requirements of sensitive, high-throughput life science applications. The syringe glass barrel is polished and coated for chemical inertness and enhanced lifetime. The needle is deactivated and coated to reduce sample adsorption. Tests with critical samples like phospholipids, basic molecules and peptides have shown that carryover and absorption are reduced depending on the sample. The plunger’s life cycle is also improved.