Polymer Packings

Hamilton Polymers - Poly(styrene divinylbenzene) or PS-DVB is a robust polymer material used as the base framework for all the Hamilton polymer HPLC packing materials.

The high degree of cross-linking with divinylbenzene makes the polymer bead extremely durable for high pressure applications.

 - Can handle pressures over 5000psi

 - Have a usable pH range of 1‐13 (allows the separation of biological samples in their natural state)

 - Polymer columns can be cleaned with 0.1 M sodium hydroxide to remove strongly retained material.

 - Swelling in organic solvents such as THF or chloroform is negligible because of the cross‐linking

 - Can be operated at much higher temperatures as compared to silica based materials

 - Excellent sample recoveries due to the lack of acidic silanol groups

 - PS‐DVB resins are similar in retention characteristics to a C18 but do have a slightly different selectivity in some cases.

LIMITATIONS OF SILICA-BASED PACKING MATERIALS:

 - Operating at pH > 10 brings along an intrinsic risk of hydrolyzing siloxane bonds in the silica matrix, which are the backbone of the porous structure

 - Continuous hydrolysis leads to deteriorating column performance

 - Species used for surface modification (silanes such as C18, C8, cyano, etc.) will elute from the column and are likely to contaminate product fractions

 - Silica-based particles dissolve in water, especially at elevated temperature and at higher pH, and in higher buffer concentrations

 - The bonded phase can easily be stripped off by pH less than 2 because the Si‐O‐Si bond is hydrolyzed, and the residual silanol sites (SiOH groups) on the surface can cause peak tailing.


PRP-1


Hamilton PRP-1 polymeric HPLC columns with 100 Å pore size particles for broad ranging uses, similar to C8 or C18 HPLC materials.
PRP-3


Hamilton PRP-3 polymeric 300 Å columns for gradient separations of peptides and proteins
PRP-h1


Hamilton PRP-h1, 100 Å C18 bonded to a polymeric support for oligonucleotides, NSAIDs and many other HPLC applications.
PRP-h5


Hamilton PRP-h5 penta fluorinated polymeric HPLC columns with 300 Å pore size particles. More hydrophilic backbone for peptide and protein separations.
PRP-Infinity


Hamilton PRP-Infinity polymer, nonporous support for very fast gradient separations of large proteins
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              Part Number
              Description
              Unit Price
              Quantity

              Compound Class

              General, chemical type or category of compound to be separated.

              Packing Material

              The type of resin that is packed inside the column tube.

              USP Class

              United States Pharmacopeia HPLC column designation.

              Particle Size

              Size (in micrometers) of the polymer or silica bead packed inside the column tube.

              Hardware ID

              Inside diameter (in millimeters) of the column tube.

              Hardware Length

              Length of the column tube (in millimeters).

              Custom Column Sizes

              Part Number
              Description
              Unit Price
              Quantity
              Semipreparative HPLC Column, CUSTOM ORDER (7.0, 7.8, 10 mm ID)
              1995.00
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              Preparative HPLC Column #1, CUSTOM ORDER (21.2, 30 mm ID)
              3780.00
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              Preparative HPLC Column #2, CUSTOM ORDER (50 mm ID)
              RFQ
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              Preparative HPLC Column #3, CUSTOM ORDER (100 mm ID)
              RFQ
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              Analytical HPLC Column [single], CUSTOM ORDER (1.0, 2.1, 4.1, 4.6 mm ID)
              805.00
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